This section contains chapter wise arrangement of Previously asked questions in MBBS Degree Examinations conducted by KUHS (Kerala University of Health Sciences)
- What is translation? Discuss the process of translation and add a note on post translational modifications (1+6+3=10)
- Describe the process of transcription. What are the post transcriptional modifications. Mention two inhibitors of transcription. (6+3+1=10)
- Discuss the process of DNA replication and mention the inhibitors of Replication. Give a note on DNA repair(6+2+2=10)
- Describe how protein is synthesized in body. Name any two inhibitors of protein biosynthesize. Add a note on post translational modifications. (6+2+2=10)
- Define replication. Describe in detail the replicative process in prokaryotes with the help of diagrams
- (1+6+3=10)
- How purine nucleotides are degraded. Add a note on abnormalities due to excessive purine catabolism. (3+2=5)
- Describe the salvage pathway of purine nucleotide synthesis with its significance. Describe the disorder associated with it.
- Name the amino acids involved in the synthesis of pyramidine
- Discuss the process of transcription in prokaryotes
- Describe the structure and functions of tRNA
- Define nucleotide. Define two adenosine nucleotide derivatives
- Mention the salient features of genetic code. Discuss in detail the various types of mutation. (3+7=10)
- Define genetic code/ What are the salient features of genetic code
- The end product of purine metabolism in human
- What is gout? Mention the causes of primary gout
- Normal serum uric acid level
- Describe uric acid formation and mention the clinical significance of its estimation.
- Define gout and name three drugs used to treat gout
- Telomerase
- Restriction endonuclease/ What are restriction endonucleases. What are their uses/ List the functions of restriction endonucleases/ Restriction enzymes
- Molecular scissors
- Reverse transcriptases
- DNA helicase
- Lesch- Nyhan syndrome/ Deficient enzyme and clinical features in Lesch – Nyhan syndrome
- Role of one carbon compounds in purine & pyrimidine formation
- Klenow fragment
- Gene therapy
- Mention the examples of partially acceptable missense mutation and unacceptable missense mutation
- Frame shift mutation
- Point mutation. Give one example for point mutation/ Examples for point mutation
- Discuss the base repair mechanism of DNA
- Disorder of defect in mismatch repair
- Xeroderma pigmentosum is due to deficiency of what process
- Disorder of defect in excision nucleotide repair
- Sickle cell anemia
- Mention two features of mitochondrial DNA
- Wobble hypothesis
- Spliceosomes
- PCR technique/Write principle and application of polymerase chain reaction
- Four applications of recombinant DNA technology
- Apoptosis
