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Sunday 29 November 2015

PHARMACOLOGY PAPER 2- 2ND MBBS KUHS- SEPTEMBER 2015



Q.P. Code: 202001                                         Reg. no.: …………………
Second Professional MBBS Degree Supplementary  Examinations, September 2015
Pharmacology- Paper II

Time: 2 Hours          Total Marks: 40

      Answer all questions
      Draw diagrams wherever necessary

Essays:         (2x6=12)

1.    List aminoglycoside  antibiotics. Mention its four common properties and two adverse effects.
2.    Read the clinical problem  and answer  the following  questions:  A 28 years old woman having two children wanted to follow a contraceptive  method.  Patient was advised to take oral contraceptive pills.  She is a known case of pulmonary tuberculosis for which she is on Rifampicin 450mg. INH300mg  and ethambutol 300mg  per day.

       What are the expected complications.
       Why.
What will you suggest
(2+2+2=6)
Short notes:
3.    Interferon alfa
4.    Therapeutic uses of glucocorticoids.
5.    Clomiphene citrate.
6.    Rabeprazole.
7.    Gatifloxacin.
(5x3=15)
Answer briefly:
(5x1=5)
8.    Rationale for the combined use of aluminium and magnesium salts in antacid preparations.
9.    Mechanism of action of co-trimoxazole.
10.  Rationale for the use of folinic acid in methotrexate toxicity.
11.  Comment on the interaction between itraconazole and omeprazole.
12.  Pharmacological basis for the combined use of drugs in cancer chemotherapy.

Name two drugs:    (8x1=8)

13.          Dermatophytosis.
14.          GERD.
15.          Brucellosis.
16.          Thyrotoxic crisis.
17.          Intestinal amoebiasis.
18.          Hookworm infestation
19.          Burns infected with pseudomonas aeruginosa 20. H1N1 viral infection.