PATHOLOGY- AIPGMEE 2011 QUESTIONS AND ANSWERS

1. Which of the following helps in generating oxygen burst in the neurophils ?
A. superoxide dismutase
B.NADPH oxidase
C. peroxidase
D. Glutathione reductase

Ans. B.NADPH oxidase
2. Which is not an autoimmune disease?
A. SLE
B. Grave's disease
C. Myasthenia gravis
D. Sickle cell disease

Ans. D. Sickle cell disease
3.An 8 year old boy completed 8 out of 10 day course of cefaclor. Now he developed a generalized erythmatic rash which is mildly pruritic and lymphadenopathy. Diagnosis is?
A. Kawasaki disease
B. Type 3 hypersensitivity
C. Anaphylaxis
D. Infectious mononucleosis

Ans. B. Type 3 hypersensitivity


4.Which among the following is the hallmark of acute inflammation?
A. Vasoconstriction
B. Stasis
C. Vasodilation and increase in permeability
D. Leukocyte margination

Ans. C. Vasodilation and increase in permeability
5. Some antigen was injected into a rabbit. What antibody will it produce initially?
A. IgG
B. IgM
C. IgA
D. IgD

Ans. B. IgM
6. Principle organelle involved in the execution of apoptosis is?
A. Nucleus
B. Lysosome
C. Mitochondria
D. Endoplasmic reticulum

Ans. C. Mitochondria

7.Psammoma bodies are seen in all except?
A. Follicular carcinoma thyroid
B. Papillary carcinoma thyroid
C. Cystadenocarcinoma
D. Meningioma

Ans. A. Follicular carcinoma thyroid
8.Not a predisposing factor for atherosclerotic plaque formation?
A. ApoE
B. Alpha 2-macroglobulin
C. Oxidised LDL
D. Increased homocystiene

Ans. B. Alpha 2-macroglobulin
9. Most potent activator of T cells?
A. B cells
B. Follicular dendritic cells
C. Mature dendritic cells
D. Macrophages

Ans. C. Mature dendritic cells
10.True about platelet function defect?
A. Normal platelet count with prolonged bleeding time
B. Thrombocytopenia with prolonged bleeding time
C. Normal bleeding time with normal platelet number
D. Normal platelet count with decreased bleeding time

A. Normal platelet count with prolonged bleeding time
11. All are true about blood coagulation except?
A. Factor 10 in a part of both intrinsic and extrinsic pathway
B. Extrinsic pathway is activated by contact with plasma and negatively charged proteins
C. Calcium is very important for coagulation
D. Intrinsic pathway can be activated in vitro

Ans. B. Extrinsic pathway is activated by contact with plasma and negatively charged proteins
12.All of the following are neuronal tumours except?
A. Gangliocytoma
B. Ganglioglioma
C. Neuroblastoma
D. Ependymoma

Ans. D. Ependymoma

13.Which complement component is first common point between involved classical and alternate pathway?
A. C1
B. C2
C. C3
D. C4

Ans. C. C3
14.All are true about xanthogranulomatous inflammation except?
A. Presence of foamy macrophages
B. Presence of tuberculous infection
C. Multinucleated giant cell
D. Presence of yellow Nodules

Ans. B. Presence of tuberculous infection
15 All are involved in generating free oxygen radical for killing of bacteria except-
A.Superoxide Dismutase
B.Fenton’s reaction
C.NADPH oxidase.
D.Glutathion peroxidase

Ans. D.Glutathion peroxidase
16. Which is false about Bernard Soulier syndrome:
A.Ristocetin Aggregation is normal
B.Aggregation with collagen & ADP is normal
C.Large platelets
D.Thrombocytopenia

Ans. A.Ristocetin Aggregation is normal
Q.17 Slide fixing in pathology most commonly done by -
A.Formaldehyde
B.Alcohol
C.Picric acid
D.Glutraldehyde

Ans. A.Formaldehyde