Q187: Differential expression of same gene depending
on parent of origin is referred to as ?
A) Genomic imprinting
B) Mosaicism
C) Anticipation
D) Nonpenetrance
Answer: A) Genomic imprinting
Q188: The chances of having an unaffected baby, when
both parents have achondroplasia, are ?
A) 0 %
B) 25 %
C) 50 %
D) 100 %
Answer: B) 25 %
Q189: Study the following carefully:
□ ○
─┬─
┌─┬─┬──┬─┐
□ ○ □ ■ ○ □
───┬───── ─┬─
┌─┬─┬─┬─┬─┐ ■
■ ■ ■ □ ○ ○
Read the pedigree. Inheritance pattern of the disease in the
family is ?
A) Autosomal recessive type
B) Autosomal dominant type
C) X Linked dominant type
D) X Linked recessive type
Answer: D) X Linked recessive type
Q190: Fibrinoid necrosis may be observed in all of
the following except ?
A) Malignant hypertension
B) Polyarteritis nodosa
C) Diabetic glomerulosclerosis
D) Aschoff's nodule
Answer: C) Diabetic glomerulosclerosis
Q191: All of the following statements are true
regarding reversible cell injury, except ?
A) Formation of amorphous densities in the mitochondrial
matrix
B) Diminished generation of adenosine triphosphate (ATP)
C) Formation of blebs in the plasma membrane
D) Detachment of ribosomes from the granular endoplasmic
reticulum
Answer: A) Formation of amorphous densities in the
mitochondrial matrix
Q192: Which of the following statements pertaining
to leukemia is correct ?
A) Blasts of acute myeloid leukemia are typically sudan
black negative
B) Blasts of acute lymphoblastic leukemia are typically
myeloperoxidase positive
C) Low leucocyte alkaline phosphatase score is characteristically
seen in blastic phase of chronic myeloid leukemia
D) Tartarate resistant acid phosphatase positivity is
typically seen in hairy cell leukemia
Answer: D) Tartarate resistant acid phosphatase positivity
is typically seen in hairy cell leukemia
Q193: In which of the following conditions bilateral
contracted kidneys are characteristically seen ?
A) Amyloidosis
B) Diabetes mellitus
C) Rapidly progressive (crescentic) glomerulonephritis
D) Benign nephrosclerosis
Answer: D) Benign nephrosclerosis
Q194: All of the following CSF findings are present
in tuberculous meningitis, except ?
A) Raised protein levels
B) Low chloride levels
C) Cob web formation
D) Raised sugar levels
Answer: D) Raised sugar levels
Q195: All of the following vascular changes are
observed in acute inflammation, except ?
A) Vasodilation
B) Stasis of blood
C) Increased vascular permeability
D) Decreased hydrostatic pressure
Answer: D) Decreased hydrostatic pressure
Q196: The subtype of Hodgkin's disease, which is
histogenetically distinct from all the other subtypes, is ?
A) Lymphocyte predominant
B) Nodular sclerosis
C) Mixed cellularity
D) Lymphocyte depleted
Answer: A) Lymphocyte predominant
Q197: In apoptosis, Apaf-1 is activated by release
of which of the following substances from the mitochondria ?
A) Bcl-2
B) Bax
C) Bcl-XL
D) Cytochrome C
Answer: D) Cytochrome C
Q198: Which type of amyloidosis is caused by
mutation of the transthyretin protein ?
A) Familial Mediterranean fever
B) Familial amyloidotic polyneuropathy
C) Dialysis associated amyloidosis
D) Prion protein associated amyloidosis
Answer: B) Familial amyloidotic polyneuropathy
Q199: In familial Mediterranean fever, the gene
encoding the following protein undergoes mutation ?
A) Pyrin
B) Perforin
C) Atrial natriuretic factor
D) Immunoglobulin light chain
Answer: A) Pyrin
Q200: Which of the following statements is not true
?
A) Patiens with IgD myeloma may present with no evident
M-spike on serum electrophoresis
B) A diagnosis of plasma cell leukemia can be made if
circulating peripheral blood plasmablasts comprise 14% of peripheral blood
white cells in a patient with white blood cell count of 11 X 100 /L and
platelet count of 88 X 109 /L
C) In smoldering myeloma plasma cells constitute 10 - 30% of
total bone marrow cellularity
D) In a patient with multiple myeloma, a monoclonal light
chain may be detected in both serum and urine
Answer: B) A diagnosis of plasma cell leukemia can be made if
circulating peripheral blood plasmablasts comprise 14% of peripheral blood
white cells in a patient with white blood cell count of 11 X 100 /L and
platelet count of 88 X 109 /L
Q201: In-situ DNA nick end labeling can quantitate ?
A) Fraction of cells in apoptotic pathways
B) Fraction of cells in S phase
C) p53 gene product
D) bcr/abl gene
Answer: A) Fraction of cells in apoptotic pathways
Q202: Which one of the following serum levels would
help in distinguishing an acute liver disease from chronic liver disease ?
A) Aminotransferase
B) Alkaline phosphatase
C) Bilirubin
D) Albumin
Answer: D) Albumin
Q203: Which one of the following stains is specific
for Amyloid ?
A) Periodic Acid Schiff (PAS)
B) Alzerian red
C) Congo red
D) Von - Kossa
Answer: C) Congo red
Q204: Which one of the following diseases
characteristically causes fatty change in liver ?
A) Hepatitis B virus infection
B) Wilson's disease
C) Hepatitis C virus infection
D) Chronic alcoholism
Answer: D) Chronic alcoholism
Q205: A 48 year old woman was admitted with a
history of weakness for two months. On examination, cervical lymph nodes were
found enlarged and spleen was palpable 2 cm below the costal margin. Her
hemoglobin was 10.5 g/dl, platelet count 237 X 109 / L and total leukocyte
count 40 X 109 /L, which included 80% mature lymphoid cells with coarse clumped
chromatin. Bone marrow revealed a nodular lymphoid infiltrate. The peripheral
blood lymphoid cells were positive for CD19, CD5, CD20, CD23 and were negative
for CD79B and FMC-7. The histopathological examination of the lymph node in
this patient will most likely exhibit effacement of lymph node architecture by
?
A) A pseudofollicular pattern with proliferation centers
B) A monomorphic lymphoid proliferation with a nodular
pattern
C) A predominantly follicular pattern
D) A diffuse proliferation of medium to large lymphoid cells
with high mitotic rate
Answer: D) A diffuse proliferation of medium to large
lymphoid cells with high mitotic rate
Q206: The most common leukocytoclastic vasculitis
affecting children is ?
A) Takayasu disease
B) Mucocutaneous lymph node syndrome (Kawasaki disease)
C) Henoch Schonlein purpura
D) Polyarteritis nodosa
Answer: C) Henoch Schonlein purpura
Q207: A four year old boy was admitted with a
history of abdominal pain and fever for two months, maculopapular rash for ten
days, and dry cough, dyspnea and wheezing for three days. On examination, liver
and spleen were enlarged 4 cm and 3 cm respectively below the costal margins.
His hemoglobin was 10.0 g/dl, platelet count 37 x 109/L and total leukocyte
count 70 x 109/L, which included 80% eosinophils. Bone marrow examination
revealed a cellular marrow comprising 45% blasts and 34% eosinophils and
eosinophilic precursors. The blasts stained negative for myeloperoxidase and
non-specific esterase and were positive for CD 19, CD 10, CD22 and CD20. Which
one of the following statements in not true about this disease ?
A) Eosinophils are not part of the neoplastic clone
B) t(5; 14) rearrangement may be detected in blasts
C) Peripheral blood eosinophilia may normalize with
chemotherapy
D) Inv (16) is often detected in the blasts and the
eosinophils
Answer: D) Inv (16) is often detected in the blasts and the
eosinophils
Q208: Kidney biopsy from a child with hemolytic
uremic syndrome characteristically most likely presents features of ?
A) Thrombotic microangiopathy
B) Proliferative glomerulonephritis
C) Focal segmental glomerulosclerosis
D) Minimal change disease
Answer: A) Thrombotic microangiopathy
Q209: The classification proposed by the
International Lymphoma Study Group for non-Hodgkin's lymphoma is known as ?
A) Kiel Classification
B) REAL Classification
C) WHO Classification
D) Rappaport Classification
Answer: B) REAL Classification
Q210: One of the intestinal enzymes that is
generally deficient in children following an attack of severe infectous
enteritis is ?
A) Lactase
B) Trypsin
C) Lipase
D) Amylase
Answer: A) Lactase
Q211: A new born presetned with bloated abdomen
shortly after birth with passing of less meconium. A full-thickness biopsy of
the rectum was carried out. Which one of the following is most likely to be
present ?
A) Fibrosis of submucosa
B) Hyalinisation of the muscular coat
C) Thickened muscularis propria
D) Lack of ganglion cells
Answer: D) Lack of ganglion cells
Q212: All of the following features are seen in the
viral pneumonia except ?
A) Presence of interstitial inflammation
B) Predominance of alveolar exudates
C) Bronchiolitis
D) Multinucleate giant cells in the bronchilar wall
Answer: B) Predominance of alveolar exudates
Q213: Type I hypersensitivity is mediated by which
of the following immunoglobulins ?
A) Ig A
B) Ig G
C) Ig M
D) Ig E
Answer: D) Ig E
Q214: Which of the following is the most common
location of hypertensive bleed in the brain ?
A) Putamen / External capsule
B) Pons
C) Ventricles
D) Lobar white matter
Answer: A) Putamen / External capsule
Q215: A woman with infertility receives an ovary
transplant from her sister who is an identical Twin. What type of graft it is ?
A) Xenograft
B) Autograft
C) Allograft
D) Isograft
Answer: D) Isograft
Q216: The following is not a feature of malignant
transformation by cultured cells ?
A) Increased cell density
B) Increased requirements for growth factors
C) Alterations of cytoskeletal structures
D) Loss of anchorage
Answer: B) Increased requirements for growth factors
Q217: A simple bacterial test for mutagenic
carcinogens is ?
A) Ames test
B) Redox test
C) Bacteriophage
D) Gene splicing
Answer: A) Ames test
Q218: In Von Hippel-Lindau Syndrome, the retinal
vascular tumors are often associated with intracranial hemangioblastoma. Which
one of the following regions is associated with such vascular abnormalities in
this syndrome ?
A) Optic radiation
B) Optic tract
C) Cerebellum
D) Pulvinar
Answer: C) Cerebellum
Q219: Aschoff's nodules are seen in ?
A) Subacute bacterial endocarditis
B) Libman-Sacks endocarditis
C) Rheumatic carditis
D) Non-bacterial thrombotic endocarditis
Answer: C) Rheumatic carditis
Q220: Which one of the following is not a feature of
liver histology in Non cirrhotic portal fibrosis (NCPF) ?
A) Fibrosis in and around the portal tracts
B) Thrombosis of the medium and small portal vein branches
C) Non specific inflammatory cell infiltrates in the portal
tracts
D) Bridging fibrosis
Answer: D) Bridging fibrosis
Q221: Which one of the following soft tissue
sarcomas frequently metastasizes to lymph nodes ?
A) Fibrosarcoma
B) Osteosarcoma
C) Embryonal Rhabdomyosarcoma
D) Alveolar soft part sarcoma
Answer: C) Embryonal Rhabdomyosarcoma
Q222: An example of a tumor suppressor gene is ?
A) myc
B) fos
C) ras
D) Rb
Answer: D) Rb
Q223: Which one of the following conditions commonly
predisposes to colonic carcinoma ?
A) Ulcerative colitis
B) Crohn's disease
C) Diverticular disease
D) Ischaemic colitis
Answer: A) Ulcerative colitis
