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Saturday 20 June 2015

PHARMACOLOGY- AIPGMEE 2006 QUESTIONS AND ANSWERS



Q68.Ethosuximide is used in the treatment of :

A.     Tonic-clonic seizure.

B.     Absence seizure.

C.     Myoclonic seizure.

D.     Simple partial seizure.

Ans: B.   Absence seizure.

Q69.Which of the following statements is not true about etomidate?

A.     It is an intravenous anesthetic.

B.     It precipitates coronary insufficiency.

C.     It inhibits cortisol synthesis.

D.     It causes pain at site of injection.

Ans: B.   It precipitates coronary insufficiency.


Q70.Which one of the following antibacterials should not be used with d-tubocurarine?

A.     Norfloxacin.

B.     Streptomycin.

C.     Doxycycline.

D.     Cefotaxime.

Ans: B.   Streptomycin.

Q71.Which one of the following drugs is an antipseudomonal penicillin?

A.     Cephalexin.

B.     Cloxacillin.


C.     Piperacillin.

D.     Dicloxacillin.

Ans: C.   Piperacillin.

Q72.The following statements regarding benzodiazephines are true except:

A.     Binds to both GABAA and GABAB receptors.

B.     They have active metabolites.

C.     Decreases nocturnal gastric secretion in human being.

D.     Extensively metabolized by CYP enzymes.

Ans: A.   Binds to both GABAA and GABAB receptors.

Q73.One of the following statements regarding mycophenolate mofetil is incorrect:

A.     It is a prodrug.

B.     It is a selective uncompetitive and reversible inhibitor of inosine monophosphate dehydrogenase.

C.     It also inhibits calcineurin.

D.     Selectivity inhibits lymphocyte proliferation.

Ans: C.   It also inhibits calcineurin.


Q74.All of the following mechanisms of action of oral contraceptive pill are true, except :

A.     Inhibition of ovulation.

B.     Prevention of fertilization.

C.     Interference with implantation of fertilized ovum.

D.     Interference with placental functioning.



Ans: D.  Interference with placental functioning.

Q75.Which one of the following drugs does not interfere with folic acid metabolism?

A.     Phenytoin.

B.     Gabapentin.

C.     Phenobarbitone.

D.     Primidone.

Ans: B.   Gabapentin.

Q76.Which one of the following drugs causes constipation?

A.     Propranolol.

B.     Verapamil.

C.     Nitroglycerin.

D.     Captopril.

Ans: D.  Captopril.

Q77.Which of the following drugs is not used topically for treatment of open angle glaucoma:

A.     Latanoprost.

B.     Brimonidine.

C.     Acetazolamide.

D.     Dorzolamide.

Ans: C.   Acetazolamide.

Q78.Concomitant administration of clonazepam with which of the following antiepileptic drug can precipitate absence status?

A.     Sodium valproate.

B.     Phenobarbitone.

C.     Carbamazepine.

D.     Phenytoin.

Ans: A.   Sodium valproate.

Q79.Which one of the following agents has been associated with hemorrhagic stroke?

A.     Phenylpropanolamine.

B.     Terfenadine.

C.     Quinidine.

D.     Fenfluramine.


Ans: A.   Phenylpropanolamine.

Q80.All of the following are therapeutic uses of Penicillin G, except :

A.     Bacterial meningitis.

B.     Rickettsial Infection.

C.     Syphilis.

D.     Anthrax.

Ans: B.   Rickettsial Infection.

Q81.All of the following are major complications of massive transfusion, except:

A.     Hypokalemia.

B.     Hypothermia.

C.     Hypomagnesemia.

D.     Hypocalcemia.

Ans: A.   Hypokalemia.

Q82.Which one of the following muscle relaxant has the maximum duration of action ?

A.     Atracurium.

B.     Vecuronium.

C.     Rocuronium.

D.     Doxacurium.

Ans: D.  Doxacurium.

Q83.Which enzyme is inhibited by Aminophylline?

A.     Monoamine Oxidase.

B.     Alcohol dehydrogenase.

C.     Phjosphodiesterase.

D.     Cytochrome P-450.


Ans: C.   Phjosphodiesterase.

Q84.Which one of the following local anesthetics belongs to the ester group?

A.     Procaine.

B.     Bupivacaine.

C.     Lignocaine.

D.     Mepivacaine.

Ans: A.   Procaine.

Q85.The following are the benozodiazepines of choice in elderly and those with liver disease, except:

A.     Lorazepam.

B.     Oxazepam,

C.     Temazepam.


D.     Diazepam.

Ans: D.  Diazepam.

Q86.Which one of the following agents sensitizes the myocardium to catecholamines?

A.     Isoflurane

B.     Ether.

C.     Halothane.

D.     Propofol.

Ans: C.   Halothane.

Q87.Which of the following is the muscle relaxant of choice in renal failure?

A.     Rapacurium

B.     Pancuronium

C.     Atracurium

D.     Rocuronium

Ans: C.   Atracurium

Q88.The most common side effect reported with treatment with haloperidol is :

A.     Hypotension.

B.     Akathisia.

C.     Dryness of mouth.

D.     Tic disorder.

Ans: B.   Akathisia.

Q89.All of the following are part of the treatment of Lithium toxicity, except:

A.     Treating dehydration.

B.     Ingestion of polystyrene sulfonate.

C.     Hemodialysis.

D.     Using an antagonist.

Ans: D.  Using an antagonist.

Q90.All are side effects of Clozapine except:

A.     Granulocytopenia.

B.     Seizures.

C.     Sedation.

D.     Extrapyramidal side effects

Ans: D.  Extrapyramidal side effects

Q91.Nevirapine is a:

A.     Protease inhibitor

B.     Nucleoside reverse transcriptase inhibitor

C.     Non-nucleoside reverse transcriptase inhibitor

D.     Fusion inhibitor

Ans: C.   Non-nucleoside reverse transcriptase inhibitor

Q92.All of the following drugs are protease inhibitors except:

A.     Nelfinavir

B.     Saquinavir

C.     Abacavir

D.     Ritonavir

Ans: C.   Abacavir

Q93.The common side effect with Fluoxetine therapy is:

A.     Seizure

B.     Anxiety

C.     Hypotension

D.     Loose stools

Ans: B.   Anxiety

Q94.A young girl has consumed barium carbonate with suicidal intent.  She complains of generalized muscle weakness.  The most likely electrolyte is:

A.     Hyponatremia

B.     Hypocalcemia

C.     Hypokalemia

D.     Hypomagnesemia


Ans: C.   Hypokalemia

Q95.All of the following antibacterial agents acts by inhibiting cell wall synthesis, except:

A.     Carbapenems.

B.     Monobactams

C.     Cephamycins

D.     Nitrofurantoin

Ans: D.  Nitrofurantoin