Q26.An affected male infant born to normal parents
could be an example of all of the following, except:
A. An
Autosomal dominant disorder.
B. An
Autosomal recessive disorder.
C. A
polygenic disorder.
D. A
vertically transmitted disorder.
Ans: A. An Autosomal dominant disorder.
Q27.The
following methods can be used to detect the point mutation in the beta globin
gene that causes sickle cell anemia, except:
A. Polymerase
chain reaction with allele-specific oligonucleotide hybridization.
B. Southern
blot analysis.
C. DNA
sequencing.
D. Northern
blot analysis.
Ans: D. Northern blot analysis.
Q28.A child with a small head, minor anomalies of the face
including a thin upper lip, growth delay, and developmental disability can have
all of the following, except:
A. A
chromosomal syndrome.
B. A
teratogenic syndrome.
C. A
Mendelian syndrome.
D. A
polygenic syndrome.
Ans: B. A teratogenic syndrome.
Q29.In a
family, the father has widely spaced eyes, increased facial hair and
deafness. One of the three children has
deafness with similar facial features.
The mother is normal. Which one
of the following is most likely pattern of inheritance in this case ?
A.
Autosomal dominant.
B.
Autosomal recessive.
C. X-linked
dominant.
D. X-linked
recessive.
Ans: D. X-linked recessive.
Q30.Mitochondrial
DNA is :
A. Closed
circular.
B. Nicked
circular.
C. Linear.
D. Open
circular.
Ans: A. Closed circular.
Q31.Polar
bodies are formed during :
A. Spermatogenesis.
B. Organogenesis.
C. Oogenesis.
D. Morphogenesis.
Ans: C. Oogenesis.
Q32.Prenatal
diagnosis at 16 weeks of pregnancy can be performed using all of the following,
except:
A. Amniotic
fluid.
B. Maternal
blood.
C. Chorionic
villi.
D. Fetal
blood.
Ans: C. Chorionic villi.
Q33.The long
and short arms of chromosomes are designated respectively as :
A. p
and q arms.
B. m
and q arms.
C. q
and p arms.
D. l
and s arms.
Ans: C. q and p arms.
Q34.Euchromatin
is the region of DNA that is relatively:
A. Uncondensed.
B. Condensed.
C. Over
condensed.
D. Partially
condensed.
Ans: D. Partially condensed.
Q35.Microsatellite
sequence is:
A. Small
satellite.
B. Extra
chromosomal DNA.
C. Short
sequence (2-5) repeat DNA.
D. Looped-DNA.
Ans: C. Short sequence (2-5) repeat DNA.
Q36.All of
the following cell types contain the enzyme telomerase which protects the
length of telomeres at the end of chromosomes, except :
A. Germinal
B. Somatic.
C. Haemopoetic.
D. Tumour.
Ans: B. Somatic.
Q37.A common
feature of all serine proteases is:
A. Autocatalytic
activation of zymogen precursor
B. Tight
binding of pancreatic trypsin inhibitor
C. Cleavage
of protein on the carboxyl site of serine residues
D. Presence
of Ser-His-Asp catalytic triad at the active site
Ans: D. Presence of Ser-His-Asp catalytic triad at the
active site
Q38.During
replication of DNA, which one of the following enzymes polymerizes the Okazaki
fragments?
A. DNA
Polymerase I
B. DNA
Polymerase II
C. DNA
Polymerase III
D. RNA
Polymerase I
Ans: DNA
Polymerase I
Q39.During
phagocytosis, the metabolic process called respiratory burst involves the
activation of:
A. Oxidase
B. Hydrolase
C. Peroxidase
D. Dehydrogenase
Ans: A. Oxidase
Q40.Which
one of the following is the complementary sequence of 5' TTAAGCTAC 3’?
A. 5’GTACGCTTAA
3’
B. 5’AATTCGCATG
3’
C. 5’CATGCGAATT
3’
D. 5’
TTAAGCGTAC 3’
Ans: A. 5’GTACGCTTAA 3’
Q41.Base
substitution mutations can have be following molecular consequences except:
A. Changes
one codon for an amino acid into another codon for that same amino acid
B. Codon
for one amino acid is changed into a codon of another amino acid
C. Reading
frame changes downstream to the mutant site
D. Codon
for one amino acid is changed into a translation termination codon
Ans: C. Reading frame changes downstream to the
mutant site
Q42.Vitamin
B12 acts as coenzyme to which one of the following enzymes?
A. Isocitrate
dehydrogenase
B. Homocysteine
methyl transferase
C. Glycogen
synthase
D. G-6-P
dehydrogenase
Ans: B. Homocysteine methyl transferase
Q43.The
normal cellular counterparts of oncogenes are important for the following
functions except:
A. Promotion
of cell cycle progression
B. Inhibition
of apoptosis
C. Promotion
of DNA repair
D. Promotion
of nuclear transcription
Ans: C. Promotion of DNA repair
Q44.The
ligand-receptor complex dissociates in the endosome because:
A. Of
its large size
B. The
vesicle looses its clathrin coat
C. Of
the acidic pH of the vesicle
D. Of
the basic pH of the vesicle
Ans: C. Of the acidic pH of the vesicle
Q45.The
amino acid which serves as a carrier of ammonia from skeletal muscle to liver
is:
A. Alanine
B. Methionine
C. Arginine
D. Glutamine
Ans: A. Alanine
Q46.All of
the following amino acids are converted to succinyl CoA, except:
A. Methionine
B. Isoleucine
C. Valine
D. Histidine
Ans: D. Histidine
Q47.The
specialized mammalian tissue/organ in which fuel oxidation serves not to
produce ATP but to generate heat is:
A. Adrenal
gland
B. Skeletal
muscle
C. Brown
adipose tissue
D. Heart
Ans: C. Brown adipose tissue
Q48.The
human plasma lipoprotein containing the highest percentage of triacylglycerol
by weight is:
A. VLDL
B. Chylomicrons
C. HDL
D. LDL
Ans: B. Chylomicrons
Q49.All of
the following enzymes are regulated by calcium or calmodulin, except:
A. Adenylate
cyclase
B. Glycogen
synthase
C. Guanylyl
cyclase
D. Hexokinase
Ans: D. Hexokinase
Q49.The
sigma subunit of prokaryotic RNA polymerase:
A. Binds
the antibiotic Rifampicin
B. Is
inhibited by amanitin
C. Specifically
recognizes the promoter site
D. Is
part of the core enzyme?
Ans:
Q50.Which
type of RNA has the highest percentage of modified base:
A. mRNA
B. tRNA
C. rRNA
D. snRNA
Ans: B. tRNA
Q51.There
are more than 300 variants of human hemoglobin gene. Among these only a few are fatal. Hence, the most important factor to be
conserved in a protein for its function is the:
A. Amino
acid sequence
B. Ligand
binding residues
C. Structure
D. Environment
Ans: A. Amino acid sequence
Q52.Proteins
are linear polymers of amino acids. They
fold into compact structures. Sometimes,
these folded structures associate to form homo or hetero-dimers. Which one of
the following refers to this associated form?
A. Denatured
state
B. Molecular
aggregation
C. Precipitation
D. Quaternary
structure
Ans: D. Quaternary structure
Q53.Which
one of the following can be a homologous substitution for isoleucine in a
protein sequence?
A. Methionine
B. Aspartic
acid
C. Valine
D. Arginine
Ans: C. Valine
Q54.The
comparison of the amino acid sequence of Cytochrome C from different species
shows many variations. Most of these
variations are found:
A. Randomly
B. Only
in helical regions
C. Only
in strand regions
D. Mainly
in loop regions
Ans: A. Randomly
Q55.The
structural proteins are involved in maintaining the shape of a cell or in the
formation of matrices in the body. The
shape of these proteins is:
A. Globular
B. Fibrous
C. Stretch
of beads
D. Planar
Ans: B. Fibrous
