ITRACONAZOLE
DOSE AND ADMINISTRATION
Recommended dose in oesophageal candidiasis Adult: As oral liquid: 200 mg daily in 1 or 2 divided doses held in the mouth for sec before swallowing. Recommended dose in prophylaxis of fungal infections in immunocompromised patients Adult: As oral liquid: 5 mg/kg daily in 2 divided doses.. Recommended dose in vulvovaginal candidiasis Adult: As capsule: 200 mg bid for 1 day.
Recommended dose in pityriasis versicolor Adult: As capsule: 200 mg daily for 7 days. Adult: As capsule: 200 mg bid for 1 day. Recommended dose in tinea corporis Adult: As capsule: 100 mg daily for 15 days or 200 mg daily for 7 days. Recommended dose in nail fungal infections Adult: As capsule: 200 mg daily for 3 mth.
Alternatively, pulse therapy with 200 bid for 7 days, repeated once for fingernail infections and twice for toenail infections after drug-free intervals of 21-days.
Recommended dose in systemic fungal infections Adult: As capsule: 100-200 mg once daily, increased to 200 mg bid for invasive disseminated infections.
USES;
Use in
oesophageal candidiasis, prophylaxis of fungal infections in immunocompromised patients,
vulvovaginal candidiasis, pityriasis versicolor,
tinea corporis,
nail fungal infections.
MONITOR;
Monitor liver function.
PHARMACOLOGY;
Itraconazole decreases ergosterol biosynthesis by interfering with cytochrome activity. This result in inhibits cell membrane function of susceptible fungi including Microsporum species, Trichophyton species, Candidaspecies, Cryptococcus neoformans, Histoplasma capsulatum, Blastomyces dermatitidis and Paracoccidiodes brasiliensis.
PRECAUTION;
• Renal insufficiency
• CHF
• history of CHF
• COPD
• Pregnancy C Category
ADR;
Dyspepsia,
abdominal pain,
nausea, vomiting, diarrhoea; menstrual disorders; constipation,
rash, pruritus, urticaria; angioedema,
anaphylaxis.
Increased liver enzyme values
jaundice,
Stevens-Johnson syndrome, hypokalaemia.
INTERACTIONS;
Concentration increased when combined with: clarithromycin, erythromycin,
HIV protease inhibitors.
Concentration decreased when combined: carbamazepine, phenobarbital,
phenytoin,
isoniazid,
rifabutin,
rifampin,
nevirapine.
Capsule absorption may be decreased antacids, H2-receptor antagonists, proton pump inhibitors.
Oral Itraconazole gets absorbed best when taken 30 minutes before a meal. Almost nil gastric side-effects. Alcohol intake should be strictly avoided during therapy with Itraconazole.🕉
DOSE AND ADMINISTRATION
Recommended dose in oesophageal candidiasis Adult: As oral liquid: 200 mg daily in 1 or 2 divided doses held in the mouth for sec before swallowing. Recommended dose in prophylaxis of fungal infections in immunocompromised patients Adult: As oral liquid: 5 mg/kg daily in 2 divided doses.. Recommended dose in vulvovaginal candidiasis Adult: As capsule: 200 mg bid for 1 day.
Recommended dose in pityriasis versicolor Adult: As capsule: 200 mg daily for 7 days. Adult: As capsule: 200 mg bid for 1 day. Recommended dose in tinea corporis Adult: As capsule: 100 mg daily for 15 days or 200 mg daily for 7 days. Recommended dose in nail fungal infections Adult: As capsule: 200 mg daily for 3 mth.
Alternatively, pulse therapy with 200 bid for 7 days, repeated once for fingernail infections and twice for toenail infections after drug-free intervals of 21-days.
Recommended dose in systemic fungal infections Adult: As capsule: 100-200 mg once daily, increased to 200 mg bid for invasive disseminated infections.
USES;
Use in
oesophageal candidiasis, prophylaxis of fungal infections in immunocompromised patients,
vulvovaginal candidiasis, pityriasis versicolor,
tinea corporis,
nail fungal infections.
MONITOR;
Monitor liver function.
PHARMACOLOGY;
Itraconazole decreases ergosterol biosynthesis by interfering with cytochrome activity. This result in inhibits cell membrane function of susceptible fungi including Microsporum species, Trichophyton species, Candidaspecies, Cryptococcus neoformans, Histoplasma capsulatum, Blastomyces dermatitidis and Paracoccidiodes brasiliensis.
PRECAUTION;
• Renal insufficiency
• CHF
• history of CHF
• COPD
• Pregnancy C Category
ADR;
Dyspepsia,
abdominal pain,
nausea, vomiting, diarrhoea; menstrual disorders; constipation,
rash, pruritus, urticaria; angioedema,
anaphylaxis.
Increased liver enzyme values
jaundice,
Stevens-Johnson syndrome, hypokalaemia.
INTERACTIONS;
Concentration increased when combined with: clarithromycin, erythromycin,
HIV protease inhibitors.
Concentration decreased when combined: carbamazepine, phenobarbital,
phenytoin,
isoniazid,
rifabutin,
rifampin,
nevirapine.
Capsule absorption may be decreased antacids, H2-receptor antagonists, proton pump inhibitors.
Oral Itraconazole gets absorbed best when taken 30 minutes before a meal. Almost nil gastric side-effects. Alcohol intake should be strictly avoided during therapy with Itraconazole.🕉
