BIOCHEMISTRY PAPER 1-1ST MBBS KUHS-2014 AUGUST

Q.P.Code:105001                                             Reg.no:…………….

First professional MBBS Degree Examinations, August 2014

BIOCHEMISTRY-PAPER I

Time: 3Hours                                           Total Marks:50

Answer all questions

Draw diagrams wherever necessary

Essay (10)

1. Describe the pathway for synthesis of urea. Add a note on the regulation of the pathway. Name two conditions in which blood urea is increased giving the biochemical basis or enzyme defect *

(5+3+2=10)

OR

Define β-oxidation. Explain reactions of β-oxidation of palmitic acid. Add a note on energetics.**

Short essays (2×5=10)

2. Kreb’s cycle*/ TCA cycle**

3. Important compounds derived from glycine

Short notes (5×3=15)

4. Enumerate three types of enzyme specificity

5. Lactose intolerance

6. Transamination

7. Significance of the HMP shunt

8. Uncouplers of oxidative phosphorylation

Answer briefly (5×2=10)

9. Active methionine

10. Biological action of glutathione

11. Hartnup’s disease

12. Clinical significance of ALP

13. Alkaptonurea

Give precise answers (5×1=5)

14. Name the deficient enzyme in Niemann Pick disease

15. Mention the normal level of serum creatinine

16. What is iso-electric pH

17. Mention any two key enzymes of glycolysis

18. Name four lipotropic factors

*Question changed

**New question